methyl 5-chloro-1H-indole-6-carboxylate synthesis
- Product Name:methyl 5-chloro-1H-indole-6-carboxylate
- CAS Number:1245643-61-1
- Molecular formula:C10H8ClNO2
- Molecular Weight:209.63
18503-89-4
86 suppliers
$60.00/500mg
1143026-45-2
20 suppliers
inquiry
1245643-61-1
42 suppliers
$100.00/100mg
Yield:1245643-61-1 52%
Reaction Conditions:
Stage #1: N,N-dimethylformamide diisopropyl acetal;methyl 2-chloro-4-methyl-5-nitrobenzoate in N,N-dimethyl-formamide at 130; for 3 h;
Stage #2: with acetic acid;zinc in water at 75 - 80;
References:
McCoull, William;Barton, Peter;Brown, Alastair J. H.;Bowker, Suzanne S.;Cameron, Jennifer;Clarke, David S.;Davies, Robert D. M.;Dossetter, Alexander G.;Ertan, Anne;Fenwick, Mark;Green, Clive;Holmes, Jane L.;Martin, Nathaniel;Masters, David;Moore, Jane E.;Newcombe, Nicholas J.;Newton, Claire;Pointon, Helen;Robb, Graeme R.;Sheldon, Christopher;Stokes, Stephen;Morgan, David [Journal of Medicinal Chemistry,2014,vol. 57,# 14,p. 6128 - 6140] Location in patent:supporting information
7697-25-8
115 suppliers
$6.00/1g
1245643-61-1
42 suppliers
$100.00/100mg
101580-96-5
17 suppliers
inquiry
1245643-61-1
42 suppliers
$100.00/100mg