ChemicalBook CAS DataBase List Miltrione

Miltrione synthesis

10synthesis methods

Product Name:Miltrione
CAS Number:27210-57-7
Molecular formula:C19H22O2
Molecular Weight:282.38

88-69-7 Synthesis

88-69-7
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$5.00/5 g

27210-57-7
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$120.00/1 mg

Yield:-

Steps:

Multi-step reaction with 10 steps
1: 87 percent / 20percent aq. NaOH / 2 h / Heating
2: 53 percent / AlCl₃ / nitrobenzene / Ambient temperature
3: 53 percent / Zn, HgCl₂, conc. HCl / H₂O; toluene / 24 h / Heating
4: 81 percent / P₂O₅, H₃PO₄ / CH₂Cl₂ / 0.33 h / 70 - 80 °C
5: 69 percent / Zn / tetrahydrofuran / 2 h
6: 62 percent / Pd-black / 2 h / 280 - 300 °C
7: 1) Mg / 1) Et₂O, 30 min 2) Et₂O, 3h
8: P₂O₅, H₃PO₄ / 0.5 h / 60 - 70 °C
9: 86 percent / BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature
10: 40 percent / Potassium nitrosodisulfonate, potassium hydrogen phosphate / acetone; H₂O

References:

Chang, Hson Mou;Cheng, Kwok Ping;Choang, Tai Francis;Chow, Hak Fun;Chui, Kuk Ying;et al. [Journal of Organic Chemistry,1990,vol. 55,# 11,p. 3537 - 3543]