![](/StructureFile/ChemBookStructure9/GIF/CB3714702.gif)
N,1,3-TRIMETHYL-1H-PYRAZOL-5-AMINE synthesis
- Product Name:N,1,3-TRIMETHYL-1H-PYRAZOL-5-AMINE
- CAS Number:103068-68-4
- Molecular formula:C6H11N3
- Molecular Weight:125.17
![Acetamide, N-(1,3-dimethyl-1H-pyrazol-5-yl)-N-methyl-](/CAS/20200611/GIF/1590502-62-7.gif)
1590502-62-7
3 suppliers
inquiry
![N,1,3-TRIMETHYL-1H-PYRAZOL-5-AMINE](/StructureFile/ChemBookStructure9/GIF/CB3714702.gif)
103068-68-4
20 suppliers
$240.00/50mg
Yield:103068-68-4 70%
Reaction Conditions:
with potassium hydroxide in ethanol;water; for 10 h;Reflux;
Steps:
3.4. Preparation of N,1,3-Trimethyl-1H-pyrazol-5-amine (15)
To a solution of N-(1,3-dimethyl-1H-pyrazol-5-yl)-N-methylacetamide (14, 7.16 g, 42 mmol) in ethanol (69 mL) was added a 5 N aqueous solution of KOH (40 mL), and the mixture was refluxed for 10 h. After this time the reaction mixture was first filtered and then evaporated under vacuum to give a residue which was extracted with diethyl ether (4 × 90 mL). The combined extracts were evaporated under reduced pressure and the obtained residue was processed by flash chromatography [13]: column external diameter 4 cm, silica gel 0.040-0.063 mm, ethyl acetate/acetone (1:1 v/v ) as eluent (1.5 L), fractions each 50 mL. The first ten fractions were discarded, and fractions 11-25 were evaporated affording pure 15 as a pale yellow oil in 70% yield. IR (KBr, cm-1): 3,228 (NH); 1H-NMR (CDCl3,ppm): 2.18 (3H, s, CH3), 2.80 (3H, s, CH3), 3.53 (4H, s, CH3, NH; 3H after exchange with D2O), 5.27(1H, s, pyrazole H-4); Anal. Calcd. for C6H11N3 (125.17) : C, 57.57%; H, 8.86%; N, 33.57%. Found:C, 57.21%; H, 8.86%; N, 33.53%.
References:
Maggio, Benedetta;Raffa, Demetrio;Raimondi, Maria Valeria;Daidone, Giuseppe [Molecules,2013,vol. 18,# 10,p. 13096 - 13110]
![1,3-Dimethyl-1H-pyrazol-5-amine](/CAS/GIF/3524-32-1.gif)
3524-32-1
182 suppliers
$5.00/250mg
![N,1,3-TRIMETHYL-1H-PYRAZOL-5-AMINE](/StructureFile/ChemBookStructure9/GIF/CB3714702.gif)
103068-68-4
20 suppliers
$240.00/50mg
![Acetamide, N-(1,3-dimethyl-1H-pyrazol-5-yl)-](/CAS/20180527/GIF/75092-37-4.gif)
75092-37-4
16 suppliers
$185.00/1g
![N,1,3-TRIMETHYL-1H-PYRAZOL-5-AMINE](/StructureFile/ChemBookStructure9/GIF/CB3714702.gif)
103068-68-4
20 suppliers
$240.00/50mg
![1H-Pyrazole-4-carboxylic acid, 5-aMino-1,3-diMethyl-, ethyl ester](/CAS/GIF/34605-62-4.gif)
34605-62-4
13 suppliers
inquiry
![N,1,3-TRIMETHYL-1H-PYRAZOL-5-AMINE](/StructureFile/ChemBookStructure9/GIF/CB3714702.gif)
103068-68-4
20 suppliers
$240.00/50mg