N-Benzylglycine ethyl ester synthesis
- Product Name:N-Benzylglycine ethyl ester
- CAS Number:6436-90-4
- Molecular formula:C11H15NO2
- Molecular Weight:193.24
Yield:6436-90-4 97.7%
Reaction Conditions:
with N-benzyl-N,N,N-triethylammonium chloride;N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 4 h;
Steps:
2.1 Preparation of intermediate IV
To the 1000 mL three-necked flask was added 43 g (0.4 mol) of benzylamine,Dichloromethane 250 mL,45.6 g (0.2 mol) of benzyltriethylammonium chloride,(12.5%) of diisopropylethylamine (l.2 mol) was stirred at room temperature,A solution of 217.3 g (1.2 mol) of ethyl 2-bromoacetate and 150 mL of methylene chloride was added dropwise. After incubation at 25-28 ° C for 4 h, the reaction was complete and the reaction solution was cooled to 0-5 ° C And the filtrate was concentrated under reduced pressure to give 75.5 g (yield 97.7%) of light brown oil (Intermediate IV) and 98.4% by HPLC. The reaction was further carried out.
References:
Chongqing weipeng Pharmaceutical Co. Ltd.;Li, Nenggang;Zou, XiaoChuan;Shi, KaiYun;Gong, Xue;Zhou, XingGuo CN105622444, 2016, A Location in patent:Paragraph 0024; 0046-0047
623-73-4
148 suppliers
$26.69/5g
100-46-9
462 suppliers
$5.00/5 g
6436-90-4
354 suppliers
$8.00/10g
17136-37-7
7 suppliers
$89.70/5g
