N,N-DI-SEC-BUTYLTHIOUREA synthesis

Yield:31182-22-6 64%

Reaction Conditions:

at 100; for 12 h;Ionic liquid;Green chemistry;

Steps:

3.1. General procedure for the synthesis of thiourea

General procedure: In a test tube equipped with magnet stirrer, an aromatic or aliphatic amine (3 mmol), carbon disulfide (5 mmol), and ionic liquid (0.5 g) were added and the reaction mixture was stirred for 12 h at 100C. After completion, the product was extracted with diethyl ether or ethyl acetate(3 × 15 ml) and the organic phase was washed with water and aqueous hydrochloric acid solution (2 M) to remove unreacted amines. Then, the organic phase was dried with anhydrous sodium sulfate and evaporated under reduced pressure to give pure thioureas in most of the cases. Further purifications have been done by recrystallization in ethanol. Cross-condensation of amines with carbon disulfide had been done by using 1.5 mmol of each amine. All the products are known and were characterized by their 1H and 13C NMR and melting points compared with those reported in the literature.

References:

Halimehjani, Azim Ziyaei;Farahbakhsh, Fataneh [Journal of Sulfur Chemistry,2013,vol. 34,# 3,p. 284 - 288]