N4-Benzoylcytosine synthesis
4synthesis methods
- Product Name:N4-Benzoylcytosine
- CAS Number:26661-13-2
- Molecular formula:C11H9N3O2
- Molecular Weight:215.21
Yield:26661-13-2 90%
Reaction Conditions:
in pyridine;methanol
Steps:
Monomer Synthesis
Benzoyl chloride (2.3 mL, 20 mmol) was added dropwise over 30 min to a stirred suspension of cytosine (1.1 g, 10 mmol) in dry pyridine, and stirring was continued at room temperature for a further 4 h at room temperature. The reaction was quenched by adding a small amount of methanol. The solid was filtered, washed with EtOH and dried in vacuo to give 1.92 g of the desired product 6 (90%).
References:
NANYANG TECHONOLOGICAL UNIVERSITY US2011/245458, 2011, A1
