ChemicalBook CAS DataBase List p-Tolunitrile

p-Tolunitrile synthesis

9synthesis methods

Product Name:p-Tolunitrile
CAS Number:104-85-8
Molecular formula:C8H7N
Molecular Weight:117.15

104-84-7
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$21.00/5g

104-85-8
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$11.00/25g

Yield:104-85-8 98%

Reaction Conditions:

with C₂₂H₂₂Cl₂FeN₂O₈^(2-)*2C₁₆H₃₆N⁽¹⁺⁾;oxygen in neat (no solvent) at 100; under 760.051 Torr; for 0.5 h;Green chemistry;

Steps:

Typical experimental procedure for aerobic oxidation of amine

General procedure: A double necked round bottomed flask (10 ml), equipped with magnetic stirrer was charged with amine (1 mmol) and catalyst 3 (5 wt %) and the resulting mixture was heated at 100 °C for 0.5 h under constant purging of molecular oxygen. After completion of the reaction, the mixture was diluted with ethyl acetate and the recovered catalyst was separated by decantation. The combined organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product, which was further purified by column chromatography over silica gel using a solvent system of hexane and ethyl acetate (4:1) as eluent.

References:

Varyani, Manish;Khatri, Praveen K.;Jain, Suman L. [Tetrahedron Letters,2016,vol. 57,# 7,p. 723 - 727]