ChemicalBook CAS DataBase List Penciclovir

Penciclovir synthesis

7synthesis methods

Product Name:Penciclovir
CAS Number:39809-25-1
Molecular formula:C10H15N5O3
Molecular Weight:253.26

9-(4-Acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine

97845-60-8
161 suppliers
$13.00/1g

39809-25-1
309 suppliers
$6.00/100mg

Yield:39809-25-1 97%

Reaction Conditions:

with hydrogenchloride in water for 3 h;Reflux;Industrial scale;Time;

Steps:

1-4; 1 Example 1. Preparation of the crystal form of the present invention
Weigh compound II (978.40g, 2.75mol) and add it to 8.25L hydrochloric acid (2mol/L), and react under reflux for 3 hours. Cool to room temperature, add NaOH solution (14mol/L),Adjust the pH to 14.0. Wash with ethyl acetate,Add hydrochloric acid (6mol/L) to the water phase,Adjust the pH to neutral, and a large number of white crystals will be precipitated. After filtering, washing and drying, 675.57 g of penciclovir was obtained with a yield of 97.0percent.The chemical purity is 99.99percent.

References:

Sichuan Keruidekaihua Pharmaceutical Co., Ltd.;Li Jiang;Li Feng;Fu Lin;Zhao Youjie;Chen Gang CN111377926, 2020, A Location in patent:Paragraph 0034-0043

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