ChemicalBook CAS DataBase List Phosphinothricin

Phosphinothricin synthesis

7synthesis methods

Product Name:Phosphinothricin
CAS Number:51276-47-2
Molecular formula:C5H12NO4P
Molecular Weight:181.13

Butanoic acid, 2-(acetylamino)-4-(ethoxymethylphosphinyl)-, ethyl ester

127985-33-5
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51276-47-2
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Yield:51276-47-2 87%

Reaction Conditions:

with hydrogenchloride in water;

Steps:

1.2 (2) Preparation of glufosinate:

first, To 51.0 g of the intermediate obtained in the step (1), 150 ml of methanol was added to dissolve,The dissolved intermediate was then transferred to an autoclave and 2.4 g of a palladium on carbon catalyst was added, followed by three replacements with nitrogen and hydrogen followed by hydrogen to 1 MPa.The temperature is raised to 50 ° C, and the hydrogen is continuously supplied during the period.Until the hydrogen pressure is no longer reduced, after the reaction is completed, it is cooled, and the catalyst is recovered by filtration.The filtrate was distilled off and the solvent was recovered in methanol. The concentrate was refluxed with 150 ml of hydrochloric acid.Excess hydrochloric acid was distilled off, and after treatment, 31.5 g of glufosinate was obtained, and the yield was 87.0%.The purity was 97.0% (HPLC, the same below).

References:

CN108191909,2018,A Location in patent:Paragraph 0012; 0029

773837-37-9 Synthesis