Pteridine (6CI,7CI,8CI,9CI) synthesis
- Product Name:Pteridine (6CI,7CI,8CI,9CI)
- CAS Number:91-18-9
- Molecular formula:C6H4N4
- Molecular Weight:132.12
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Yield:-
Reaction Conditions:
with sodium hydroxide;sodium hydrogensulfite in water
Steps:
1 EXAMPLE 1
EXAMPLE 1 Production of 2,4-diamino-6-methylpteridine: 23.8 g of 2,4,5,6-tetramino pyrimidine sulfate (0.1 mole) was suspended in 750 ml of H2 O and mixed in sequence with 16.8 g of sodium bisulfite and 26 g (0.2 mole) of 1,1-dichloroacetone. The mixture was allowed to react at 60° C. while stirring. At the same time the pH was kept constant by the addition as needed of 1 N caustic soda solution. When no further NaOH consumption was found (after 5 to 6 hours), the reaction mixture was allowed to cool to ambient temperature and was mixed with NaOH up to pH 7. The desired pteridine was obtained thereby as orange colored crystals and was isolated by filtration. The yield was 8.8 g (50 percent of theoretical) of NMR-pure 6-methyldiaminopteridine that was free of isomers.
References:
Lonza Ltd. US4224446, 1980, A
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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91-18-9
13 suppliers
$439.00/1g
1000210-73-0
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inquiry
91-18-9
13 suppliers
$439.00/1g