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105950-89-8

Pyrimidine, 4-chloro-2-(methoxymethyl)- synthesis

2synthesis methods
Pyrimidine, 4-chloro-2-(methoxymethyl)-

105950-89-8
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Yield:-

Reaction Conditions:

with trichlorophosphate

Steps:

1.b 2-[4-Morpholino-2-pyrimidinylmethylsulfinyl]-1H-thieno[3,4-d]imidazole

(b) A suspension of 100 g of 2-methoxymethyl-4-pyrimidone and 500 ml of phosphorus oxychloride was slowly heated until a clear solution formed. Excess phosphorus oxychloride was distilled, the residue was hydrolyzed with ice-water, and the pH was adjusted to 10 with sodium hydroxide solution. Extraction with dichloromethane followed by purification by column chromatography resulted in 101 g of 2-methoxymethyl-4-chloropyrimidine as an oil.

References:

US4956366,1990,A