Pyrimidine, 4-chloro-2-(methoxymethyl)- synthesis
- Product Name:Pyrimidine, 4-chloro-2-(methoxymethyl)-
- CAS Number:105950-89-8
- Molecular formula:C6H7ClN2O
- Molecular Weight:158.59
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Yield:-
Reaction Conditions:
with trichlorophosphate
Steps:
1.b 2-[4-Morpholino-2-pyrimidinylmethylsulfinyl]-1H-thieno[3,4-d]imidazole
(b) A suspension of 100 g of 2-methoxymethyl-4-pyrimidone and 500 ml of phosphorus oxychloride was slowly heated until a clear solution formed. Excess phosphorus oxychloride was distilled, the residue was hydrolyzed with ice-water, and the pH was adjusted to 10 with sodium hydroxide solution. Extraction with dichloromethane followed by purification by column chromatography resulted in 101 g of 2-methoxymethyl-4-chloropyrimidine as an oil.
References:
US4956366,1990,A
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105950-89-8
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