Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List quinoline-8-carbonyl chloride
100517-41-7

quinoline-8-carbonyl chloride synthesis

2synthesis methods
-

Yield:100517-41-7 92%

Reaction Conditions:

with dichloro sulfoxide in 1,2-dichloro-ethane;N,N-dimethyl-formamide; for 5 h;Reflux;

Steps:

8.1 The first reaction: the preparation of quinoline-8-carbonyl chloride

At room temperature, add quinoline-8-carboxylic acid (2.60g, 0.015mol), dichloroethane (30ml), and N, N-dimethylformamide (0.05g) to a three-necked flask.To the above mixture was added dropwise dichlorosulfoxide (2.38 g, 0.02 mol).Heat to reflux for 5 hours.The heating was stopped, and the solvent and residual dichlorosulfoxide were removed under reduced pressure to obtain 2.64 g of the product with a yield of 92 %

References:

CN110615781,2019,A Location in patent:Paragraph 0269; 0271; 0272