rac 1-Lauroyl-3-chloropropanediol synthesis
- Product Name:rac 1-Lauroyl-3-chloropropanediol
- CAS Number:20542-96-5
- Molecular formula:C15H29ClO3
- Molecular Weight:292.84
143-07-7
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106-89-8
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$9.00/10g
20542-96-5
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$425.00/10mg
Yield:20542-96-5 80%
Reaction Conditions:
with tetrabutylammomium bromide in ethanol at 85; for 15 h;
Steps:
Synthesis of 3-alkyl Acyloxy-2-hydroxy Chloropropane
General procedure: 30 mmollauric acid (6.01 g)/ myristic acid (6.85 g)/palmitic acid (7.70 g)/ stearic acid (8.53 g) and 0.3mmol(0.10 g) tetrabutylammonium bromide (TBAB) were dissolvedin 35 mL ethanol in a 100 mL round flask. 4 mL(4.72 g, 51mmol) epichlorohydrin was added drop wise intothe flask under 85 oC. The reaction solution was kept for 15h and stopped when the acid value of fatty acid was <1 mgKOH. Excess ethanol was removed under vacuum and theresidue was washed by distilled hot water three times. Waterwas removed under vacuum. The product was obtained in80% yield and was used for next synthesis without furtherpurified.
References:
Yu, Erlei;Mamat, Xamxikamar;Zhang, Yagang;Eli, Wumanjiang [Letters in Organic Chemistry,2015,vol. 12,# 8,p. 591 - 597]
112-16-3
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96-24-2
291 suppliers
$11.00/5g
20542-96-5
10 suppliers
$425.00/10mg