Ropivacaine hydrochloride synthesis
- Product Name:Ropivacaine hydrochloride
- CAS Number:132112-35-7
- Molecular formula:C17H26N2O.ClH.H2O
- Molecular Weight:328.88
84057-95-4
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132112-35-7
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Yield:132112-35-7 82%
Reaction Conditions:
with hydrogenchloride;water in acetone; pH=2;Product distribution / selectivity;Heating / reflux;
Steps:
11
About 3 g of Ropivacaine base was dissolved in 10 mL of water and to this solution was added 50 mL of hot acetone and conc. Hydrochloride acid was added slowly with stirring until pH reaches 2 and heated to reflux until the solution becomes clear solution. 20 mL of acetone was added and the precipitated solid was filtered, washed with acetone and dried to give L-Ropivacaine hydrochloride monohydrate 2.9 g, yield 82% Water content: 5.6%
References:
US2006/276654,2006,A1 Location in patent:Page/Page column 5
98717-15-8
233 suppliers
$49.00/25mg
132112-35-7
338 suppliers
$49.00/25mg