SILATRANE synthesis

5synthesis methods

Product Name:SILATRANE
CAS Number:283-60-3
Molecular formula:C6H13NO3Si
Molecular Weight:175.26

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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2,8,9-Trioxa-5-aza-1-silabicyclo[3.3.3]undecane-1-propanethiol

29909-46-4
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283-60-3
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Yield: 89%

Reaction Conditions:

with sodium methylate in methanol;toluene

Steps:

2 Production of compound No. 4 of the invention (second process)
EXAMPLE 2 Production of compound No. 4 of the invention (second process) The same reactor as used in Example 1 was charged with 2.49 g (0.01 mole) of 1-(3-mercaptopropyl)silatrane and 100 ml of toluene, and the silatrane derivative was well dissolved. With stirring, 1.93 g (0.01 mole) of a methanol solution of sodium methylate (concentration 28%) was added dropwise. Then, 20 ml of a toluene solution of 5.54 g (0.01 mole) of trineophyltin chloride was added dropwise with stirring. The mixture was heated at 100° C. for 30 minutes to complete the reaction. The sodium chloride formed was removed by hot filtration. The filtrate was concentrated to give 7.7 g of a white solid. Recrystallization from ethanol gave 6.8 g (yield 89%) of 1-(3-trineophylstannylthiopropyl)silatrane as white crystals having a melting point of 104° to 106° C.

References:

Nitto Kasei Co., Ltd. US4654368, 1987, A

2487-90-3 Synthesis