sodium 4-oxovalerate synthesis

Yield:-

Reaction Conditions:

with sodium hydroxide in water;

Steps:

40

[0531] Example 40 2.52 g (0.02 mol) of levulinic acid and 47.57g methyl isobutyl ketone (MIBK) were added to a 250 mL beaker and mixed thoroughly until homogeneous. To this mixture, 1.75g of a 50/50 wt% sodium hydroxide solution was added. As soon as the sodium hydroxide was added, a white precipitate formed. A magnetic stir bar was placed into the beaker and put onto a stir plate to stir for a few minutes. With stirring, it appeared as though more precipitate formed. The precipitate was then filtered out using vacuum filtration and a 0.45μιη filter. A small amount of the precipitate was put into a GC vial and dissolved with water and then run on the HPLC to be analyzed. The analysis showed that the sodium salt of levulinic acid was synthesized.

References:

WO2014/189991,2014,A1 Location in patent:Paragraph 0531