What is Ribociclib?

Ribociclib is an orally available cyclin-dependent kinase (CDK) inhibitor targets at cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

Uses

Ribociclib is used in combination with an aromatase inhibitor to treat pre/perimenopausal or postmenopausal women with breast cancer

Ribociclib is used in combination with fulvestrant to treat postmenopausal women with breast cancer

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How Ribociclib Is Given

Ribociclib is a tablet given by mouth. Tablets should be swallowed whole. Do not crush, chew, or split tablets.

It may be taken with or without food

Do not eat pomegranate, grapefruit or drink pomegranate or grapefruit juice while on ribociclib.

Ribociclib should be taken at the same time each day with letrozole (or other aromatase inhibitors)

If you miss a dose of ribociclib, take it as soon as you remember that day. If you miss taking your dose for the entire day, go back to taking your regular dose the next day. Do not take 2 doses at the same time.

The amount of ribociclib that you will receive depends on many factors, including your general health or other health problems, and the type of cancer or condition you have. Your doctor will determine your exact dosage and schedule.

Side Effects

Important things to remember about the side effects of ribociclib:

Most people will not experience all of the ribociclib side effects listed.

Ribociclib side effects are often predictable in terms of their onset, duration, and severity.

Ribociclib side effects will improve after therapy is complete.

Ribociclib side effects may be quite manageable. There are many options to minimize or prevent the side effects of ribociclib.

Ribociclib is an orally available cyclin-dependent kinase (CDK) inhibitor targets at cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

Uses

Ribociclib is used in combination with an aromatase inhibitor to treat pre/perimenopausal or postmenopausal women with breast cancer

Ribociclib is used in combination with fulvestrant to treat postmenopausal women with breast cancer

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How Ribociclib Is Given

Ribociclib is a tablet given by mouth. Tablets should be swallowed whole. Do not crush, chew, or split tablets.

It may be taken with or without food

Do not eat pomegranate, grapefruit or drink pomegranate or grapefruit juice while on ribociclib.

Ribociclib should be taken at the same time each day with letrozole (or other aromatase inhibitors)

If you miss a dose of ribociclib, take it as soon as you remember that day. If you miss taking your dose for the entire day, go back to taking your regular dose the next day. Do not take 2 doses at the same time.

The amount of ribociclib that you will receive depends on many factors, including your general health or other health problems, and the type of cancer or condition you have. Your doctor will determine your exact dosage and schedule.

Side Effects

Important things to remember about the side effects of ribociclib:

Most people will not experience all of the ribociclib side effects listed.

Ribociclib side effects are often predictable in terms of their onset, duration, and severity.

Ribociclib side effects will improve after therapy is complete.

Ribociclib side effects may be quite manageable. There are many options to minimize or prevent the side effects of ribociclib.