| Identification | Back Directory | [Name]
1H-Benzo[a]fluorene-7,9-diol, 2,3,4,4a,5,6,6a,11,11a,11b-decahydro-4,4,6a,11b-tetramethyl-, (4aS,6aR,11aR,11bS)- | [CAS]
1000010-33-2 | [Synonyms]
AQXMN115
AQX-MN115
AQX MN115
1H-Benzo[a]fluorene-7,9-diol, 2,3,4,4a,5,6,6a,11,11a,11b-decahydro-4,4,6a,11b-tetramethyl-, (4aS,6aR,11aR,11bS)- | [Molecular Formula]
C21H30O2 | [MOL File]
1000010-33-2.mol | [Molecular Weight]
314.46 |
| Hazard Information | Back Directory | [Description]
AQX-MN115 is a SH2-?containing inositol 5-?phosphatase (SHIP 1) modulator. | [Uses]
SHIP1 activator 1 is an SH3 domain-containing inositol 5-phosphatase regulator with SHIP1 activating activity. SHIP1 activator 1 retains its SHIA-1 activating ability by removing unnecessary functional groups. SHIP1 activator 1 is able to activate SHIP1 in vitro, inhibit Akt phosphorylation in MOLT-4 cells, and show dose-dependent activity in a mouse model of inflammation. SHIP1 activator 1 is an important chemical tool for evaluating the potential of SHIP1 activators as inhibitors of hematopoietic diseases involving abnormal PI3K cell signaling[1]. | [References]
[1] Synthesis of SHIP1-Activating Analogs of the Sponge Meroterpenoid Pelorol |
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