| Identification | Back Directory | [Name]
flazin | [CAS]
100041-05-2 | [Synonyms]
flazin
Flazine
1-[5-(Hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic acid
9H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-[5-(hydroxymethyl)-2-furanyl]- | [Molecular Formula]
C17H12N2O4 | [MDL Number]
MFCD34167427 | [MOL File]
100041-05-2.mol | [Molecular Weight]
308.29 |
| Chemical Properties | Back Directory | [Melting point ]
218-220 °C (decomp) | [Boiling point ]
657.1±55.0 °C(Predicted) | [density ]
1.513±0.06 g/cm3(Predicted) | [pka]
1.30±0.30(Predicted) | [InChI]
InChI=1S/C17H12N2O4/c20-8-9-5-6-14(23-9)16-15-11(7-13(19-16)17(21)22)10-3-1-2-4-12(10)18-15/h1-7,18,20H,8H2,(H,21,22) | [InChIKey]
USBWYUYKHHILLZ-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC=C2)C2C=C(C(O)=O)N=C(C3=CC=C(CO)O3)C1=2 |
| Hazard Information | Back Directory | [Uses]
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO-), with an IC50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor[1][2][3]. | [Definition]
ChEBI: A natural product found in Cordyceps sinensis. | [References]
[1] Seong SH, et al. Discovery of Flazin, an Alkaloid Isolated from Cherry Tomato Juice, As a Novel Non-Enzymatic Protein Glycation Inhibitor viain Vitro and in Silico Studies. J Agric Food Chem. 2021 Mar 31;69(12):3647-3657. DOI:10.1021/acs.jafc.0c07486
[2] Wu X, et al. Flazin as a Lipid Droplet Regulator against Lipid Disorders. Nutrients. 2022 Apr 3;14(7):1501. DOI:10.3390/nu14071501
[3] Li H, et al. Effect of Soy Sauce on Serum Uric Acid Levels in Hyperuricemic Rats and Identification of Flazin as a Potent Xanthine Oxidase Inhibitor. J Agric Food Chem. 2016 Jun 15;64(23):4725-34. DOI:10.1021/acs.jafc.6b01094 |
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