| Identification | Back Directory | [Name]
AMG-747 | [CAS]
1000690-85-6 | [Synonyms]
AMG-747
Tilapertin
1-Piperazineacetic acid, 4-[(R)-phenyl[3-(trifluoromethyl)phenyl]methyl]-
2-[4-[(R)-phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]acetic acid | [Molecular Formula]
C20H21F3N2O2 | [MDL Number]
MFCD30532732 | [MOL File]
1000690-85-6.mol | [Molecular Weight]
378.39 |
| Chemical Properties | Back Directory | [Boiling point ]
455.3±45.0 °C(Predicted) | [density ]
1.276±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
4.24±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1). | [in vivo]
Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats[1]. | [IC 50]
GlyT1 | [References]
[1] Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97. DOI:10.1016/j.schres.2016.10.027 |
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