| Identification | Back Directory | [Name]
PiMecroliMus hydrate(1:x) | [CAS]
1000802-56-1 | [Synonyms]
PubChem ID: 91886159
Pimecrolimus hydrate
PiMecroliMus hydrate(1:x)
NZIZEODSJUZSHZ-ZYRXJNKISA-N | [Molecular Formula]
C43H70ClNO12 | [MOL File]
1000802-56-1.mol | [Molecular Weight]
828.48 |
| Hazard Information | Back Directory | [Uses]
Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus[1][2][3]. | [in vivo]
Pimecrolimus hydrate (10, 30 mg/kg; p.o.; daily for 4 weeks) increases in absolute numbers of T lymphocytes in KLH-immunised rats compared with non-immunised animals[2]. | [References]
[1] Grassberger M, et al. Pimecrolimus -- an anti-inflammatory drug targeting the skin. Exp Dermatol. 2004 Dec;13(12):721-30. DOI:10.1111/j.0906-6705.2004.00269.x
[2] Roman D, et al. Determination of the effect of calcineurin inhibitors on the rat's immune system after KLH immunisation. Toxicol Lett. 2004 Apr 1;149(1-3):133-40. DOI:10.1016/j.toxlet.2003.12.027
[3] Passeron T, et al. Treatment of oral erosive lichen planus with 1% pimecrolimus cream: a double-blind, randomized, prospective trial with measurement of pimecrolimus levels in the blood. Arch Dermatol. 2007 Apr;143(4):472-6. DOI:10.1001/archderm.143.4.472 |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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