| Identification | Back Directory | [Name]
4-Amino-2-fluoro-5-methoxybenzoic acid | [CAS]
1001346-91-3 | [Synonyms]
4-Amino-2-fluoro-5-methoxybenzoic acid
Benzoic acid, 4-amino-2-fluoro-5-methoxy-
4-Amino-2-fluoro-5-methoxybenzoic acid USP/EP/BP | [Molecular Formula]
C8H8FNO3 | [MDL Number]
MFCD11849929 | [MOL File]
1001346-91-3.mol | [Molecular Weight]
185.15 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [Appearance]
Light yellow to brown Solid | [InChI]
InChI=1S/C8H8FNO3/c1-13-7-2-4(8(11)12)5(9)3-6(7)10/h2-3H,10H2,1H3,(H,11,12) | [InChIKey]
AOFWIQANMFITAG-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=CC(OC)=C(N)C=C1F |
| Hazard Information | Back Directory | [Synthesis]
A solution of 2-fluoro-5-methoxy- 4-nitrobenzoic acid (10 g, 46 mmol), HOAc (50 mL), and MeOH (50 mL) was hydrogenated using a hydrogen balloon overnight. The solution was then filtered through celite and concentrated to a residue, which was triturated with ether and ethyl acetate. The solid was filtered and dried to give the product 4-Amino-2-fluoro-5-methoxybenzoic acid as a light yellow powder (8.3 g, 98 %).
| [References]
[1] Patent: WO2009/42711, 2009, A1. Location in patent: Page/Page column 266
[2] Patent: US2008/9482, 2008, A1. Location in patent: Page/Page column 134
[3] Patent: WO2008/40951, 2008, A1. Location in patent: Page/Page column 150
[4] Patent: WO2008/40951, 2008, A1. Location in patent: Page/Page column 150
[5] Patent: WO2009/42711, 2009, A1. Location in patent: Page/Page column 387-388 |
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