| Identification | Back Directory | [Name]
2-Pyridinecarboxamide,4-amino-(9CI) | [CAS]
100137-47-1 | [Synonyms]
4-AMinopicolinaMide
4-amino-2-Pyridinecarboxamide
2-Pyridinecarboxamide, 4-amino-
2-Pyridinecarboxamide,4-amino-(9CI) | [Molecular Formula]
C6H7N3O | [MDL Number]
MFCD08062892 | [MOL File]
100137-47-1.mol | [Molecular Weight]
137.14 |
| Chemical Properties | Back Directory | [Melting point ]
169 °C | [Boiling point ]
413.0±30.0 °C(Predicted) | [density ]
1.323±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
15.33±0.50(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C6H7N3O/c7-4-1-2-9-5(3-4)6(8)10/h1-3H,(H2,7,9)(H2,8,10) | [InChIKey]
QKNCZYUYGMWQPB-UHFFFAOYSA-N | [SMILES]
C1(C(N)=O)=NC=CC(N)=C1 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-aminopyridinamide (99B) from 4-nitro-2-pyridine carboxamide (99A): 99A (40 mg) was dissolved in methanol, 10% Pd/C catalyst (40 mg) was added, and the hydrogenation reaction was carried out for 8 hours under the atmosphere of a hydrogen balloon. Upon completion of the reaction, the Pd/C catalyst was removed by filtration. The filtrate was concentrated to give a white solid 99B (80 mg, 87% yield). The product was characterized by 1H NMR (400 MHz, methanol-d4): δ 6.65 (dd, J = 5.71, 2.64 Hz, 1H), 7.27 (d, J = 2.20 Hz, 1H), 8.03 (d, J = 5.71 Hz, 1H). | [References]
[1] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 76-77 |
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