| Chemical Properties | Back Directory | [Boiling point ]
517.6±50.0 °C(Predicted) | [density ]
1.380±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [pka]
13.44±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases[1]. | [IC 50]
P2X7 Receptor | [References]
[1] MUNA H. ABDI. Discovery and structure–activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20 17: Pages 5080-5084. DOI: 10.1016/j.bmcl.2010.07.033
[2] GERMAIN HOMERIN. Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease[J]. Journal of Medicinal Chemistry, 2019, 63 5: 2074-2094. DOI: 10.1021/acs.jmedchem.9b00584
[3] ZHI RUAN. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice.[J]. ACS Combinatorial Science, 2020: 47. DOI: 10.1186/s13024-020-00396-2 |
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| Company Name: |
PURALABS
|
| Tel: |
+918985212143 |
| Website: |
www.puralabs.co.in |
|