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1002726-62-6

1002726-62-6 Structure

1002726-62-6 Structure
IdentificationBack Directory
[Name]

6-AMINO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
[CAS]

1002726-62-6
[Synonyms]

6-AMino-2,2-diMethyl-2H-p...
6-Amino-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3
6-Amino-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)
6-AMINO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-aMino-2,2-diMethyl-
6-amino-2,2-dimethyl-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-3-one
[Molecular Formula]

C9H11N3O2
[MDL Number]

MFCD10000812
[MOL File]

1002726-62-6.mol
[Molecular Weight]

193.2
Chemical PropertiesBack Directory
[Boiling point ]

420.3±45.0 °C(Predicted)
[density ]

1.256
[storage temp. ]

Keep in dark place,Sealed in dry,2-8°C
[pka]

10.79±0.40(Predicted)
Questions And Answer(Q&A)Back Directory
[Application]

6-amino-2,2-dimethyl-4H-pyrido[3,2-b]oxazin-3-one is the key intermediate of Fostamatinib, which is a medication approved by the U.S. Food and Drug Administration since 2018 for the treatment of chronic immune thrombocytopenia (ITP). Fostamatinib is administered orally as a disodium hexahydrate salt and is a prodrug of the active compound tamatinib (R-406), which is a competitive spleen tyrosine kinase (Syk) inhibitor for ATP binding.
Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors, including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes, including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development and plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens.
Spectrum DetailBack Directory
[Spectrum Detail]

6-AMINO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE(1002726-62-6)1HNMR
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