| Identification | Back Directory | [Name]
BAY R3401 | [CAS]
100276-03-7 | [Synonyms]
BAY R3401 >=98% (HPLC), solid
4-(2-Chlorophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylic acid isopropyl ester
Furo[3,4-b]pyridine-3-carboxylic acid, 4-(2-chlorophenyl)-1-ethyl-1,4,5,7-tetrahydro-2-methyl-5-oxo-, 1-methylethyl ester | [Molecular Formula]
C20H22ClNO4 | [MDL Number]
MFCD08705409 | [MOL File]
100276-03-7.mol | [Molecular Weight]
375.85 |
| Chemical Properties | Back Directory | [Melting point ]
110-112 °C | [Boiling point ]
512.6±50.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble15mg/mL | [form ]
solid | [pka]
-0.68±0.70(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
BAY R3401 is an orally active glycogen phosphorylase inhibitor that can achieve irreversible and non-selective inhibition of hepatic glycogenolysis. BAY R3401 inhibits glycogenolysis in liver cells, with IC50 values of 27.06 and 52.83 μM in HL-7702 and HepG2 cells, respectively. BAY R3401 can be used for the research of type 2 diabetes[1]. | [References]
[1] Zhang L, et al. Design, Synthesis, and Biological Application of Novel Photoaffinity Probes of Dihydropyridine Derivatives, BAY R3401. Molecules. 2019 Jun 28;24(13):2394. DOI:10.3390/molecules24132394 |
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