ChemicalBook--->CAS DataBase List--->100307-95-7

100307-95-7

100307-95-7 Structure

100307-95-7 Structure
IdentificationBack Directory
[Name]

2-aminobenzoylalanyl-glycyl-leucyl-alanyl-4-nitrobenzylamide
[CAS]

100307-95-7
[Synonyms]

AAGLAN
2-Aminobenzoyl-Ala-Gly-Leu-Ala-p-nitrobenzylamide
2-aminobenzoylalanyl-glycyl-leucyl-alanyl-4-nitrobenzylamide
L-Alaninamide, N-(2-aminobenzoyl)-L-alanylglycyl-L-leucyl-N-[(4-nitrophenyl)methyl]-
2-amino-N-[(2S)-1-[[2-[[(2S)-4-methyl-1-[[(2S)-2-[(4-nitrophenyl)methylamino]propanoyl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]benzamide
[Molecular Formula]

C28H37N7O7
[MDL Number]

MFCD00237463
[MOL File]

100307-95-7.mol
[Molecular Weight]

583.64
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
[Sequence]

{Abz}-Ala-Gly-Leu-Ala-{p-Nitrobenzylamide}
Hazard InformationBack Directory
[Uses]

Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal[1].
[References]

[1] Everett MJ, et, al. Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models. ACS Infect Dis. 2023 Feb 10;9(2):270-282. DOI:10.1021/acsinfecdis.2c00418
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