| Chemical Properties | Back Directory | [Boiling point ]
720.7±70.0 °C(Predicted) | [density ]
1.367±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (63.23 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
4.85±0.26(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1]. | [in vivo]
c-Kit-IN-5 (compound 25) (1 mg/kg; i.v.) exhibits CL (0.46 L/h/kg) and Vdss (1.59 L/kg) in rats[1].
c-Kit-IN-5 (10 mg/kg; p.o.) exhibits AUC0-t(9860 ng?h/mL) Cmax(1230 ng/mL), T1/2 (2.6 h), and F (39%) in rats[1]. | [storage]
Store at -20°C | [References]
[1] Hu E, et, al. Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit. J Med Chem. 2008 Jun 12;51(11):3065-8. DOI:10.1021/jm800188g |
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| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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