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1004312-94-0

1004312-94-0 Structure

1004312-94-0 Structure
IdentificationBack Directory
[Name]

1-Azoniabicyclo[2.2.2]octane, 3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino]carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-, bromide,(3R)-
[CAS]

1004312-94-0
[Synonyms]

CHF5407
M3 receptor antagonist 1
1-Azoniabicyclo[2.2.2]octane, 3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino]carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-, bromide,(3R)-
[Molecular Formula]

C27H25BrF4N2O3S
[MDL Number]

MFCD31544422
[MOL File]

1004312-94-0.mol
[Molecular Weight]

613.462
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

CHF5407 is a potent, long-acting, and selective muscarinic M3 receptor antagonist.
[Uses]

CHF5407 is a selective, long-acting and competitive muscarinic M3 receptor antagonist. CHF5407 shows subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors. CHF5407 shows a prolonged antibronchospastic activity[1].
[in vivo]

CHF5407 (0.1, 0.3, 1 nmol/kg; intratracheally; 100 ul; sigle dose) exerted a dose-dependent and potent inhibition of ACh-induced (20 g/kg; i.v.) bronchospasm, with an ED50 value of 0.15 nmol/kg in guinea pigs (450-550 g)[1].

[References]

[1] G Villetti, et al. Bronchodilator activity of (3R)-3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino] carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyclo[2.2.2]octane bromide (CHF5407), a potent, long-acting, and selective muscarinic M3 rec DOI:10.1124/jpet.110.170035
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