ChemicalBook--->CAS DataBase List--->100481-09-2

100481-09-2

100481-09-2 Structure

100481-09-2 Structure
IdentificationBack Directory
[Name]

2-Thiazolesulfonyl chloride
[CAS]

100481-09-2
[Synonyms]

Thiazolesulfonyl chloride
2-THIAZOLESULFONYL CHLORIDE
thiazole-2-sulfonyl chloride
2-Thiazolesulfonylchloride(9CI)
1,3-thiazole-2-sulfonyl chloride
2-Thiazolesulfonyl chloride ISO 9001:2015 REACH
[Molecular Formula]

C3H2ClNO2S2
[MDL Number]

MFCD08460252
[MOL File]

100481-09-2.mol
[Molecular Weight]

183.64
Chemical PropertiesBack Directory
[Boiling point ]

328.5±25.0 °C(Predicted)
[density ]

1.687±0.06 g/cm3(Predicted)
[storage temp. ]

-86?C Freezer, Under Inert Atmosphere
[solubility ]

Chloroform (Slightly), Ethyl Acetate (Slightly)
[form ]

Oil
[pka]

-3.33±0.10(Predicted)
[color ]

Clear Pale Yellow to Yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Chemical Properties]

Yellow Oil
[Uses]

2-Thiazolesulfonyl chloride is used for preparation of substituted thiazolesulfonamides as antiglaucoma agents.
[Synthesis]

To a suspension of 2-mercaptothiazole (0.16 g, 1.37 mmol) in CH2Cl2 (14 mL) was added water (7 mL) followed by N-chlorosuccinimide (0.75 g, 5.6 mmol). The reaction mixture was stirred vigorously for 1.5 h. The reaction mixture was diluted with CH2Cl2, was
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