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1006002-58-9

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1006002-58-9 Structure

1006002-58-9 Structure
IdentificationBack Directory
[Name]

ICOS-IN-1
[CAS]

1006002-58-9
[Synonyms]

ICOS-IN-1
[Molecular Formula]

C17H14Cl2N2O2
[MOL File]

1006002-58-9.mol
[Molecular Weight]

349.21
Chemical PropertiesBack Directory
[Boiling point ]

548.529±50.00 °C(Press: 760.00 Torr)(predicted)
[density ]

1.399±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka]

8.740±0.40(predicted)
Hazard InformationBack Directory
[Uses]

ICOS-IN-1 (compound 9) is an inhibitor of the interaction between ICOS and ICOS-L (IC50=29.38 μM) and has activity in recognizing immune checkpoints[1].
[References]

[1] Longfei Zhang, et al. "Discovery of ICOS-targeted small molecules using affinity selection mass spectrometry screening."?bioRxiv?(2024): 2024-08. DOI:10.1101/2024.08.04.606538
1006002-58-9 suppliers list
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Website: https://www.targetmol.cn/
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