| Identification | Back Directory | [Name]
2,4-pyrimidinediamine, 6-chloro-N~4~,N~4~-dimethyl- | [CAS]
1007-11-0 | [Synonyms]
6-chloro-N',N'-dimethylpyrimidine-2,4-diamine
6-chloro-N',N'-dimethyl-pyrimidine-2,4-diamine
6-chloro-4-N,4-N-dimethylpyrimidine-2,4-diamine
(2-amino-6-chloro-pyrimidin-4-yl)-dimethyl-amine
2-Amino-6-chloro-4-(dimethylamino)pyrimidine, 97%
6-chloro-N~4~,N~4~-dimethylpyrimidine-2,4-diamine
6-chloro-N~4~,N~4~-dimethyl-2,4-pyrimidinediamine
2,4-pyrimidinediamine, 6-chloro-N~4~,N~4~-dimethyl-
6-chloro-N~4~,N~4~-dimethyl-2,4-pyrimidinediamine(SALTDATA: FREE) | [Molecular Formula]
C6H9ClN4 | [MDL Number]
MFCD13188630 | [MOL File]
1007-11-0.mol | [Molecular Weight]
172.62 |
| Chemical Properties | Back Directory | [Boiling point ]
384.4±45.0 °C(Predicted) | [density ]
1.347±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
4.00±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 6-chloro-N4,N4-dimethylpyrimidine-2,4-diamine from 2-amino-4,6-dichloropyrimidine and dimethylamine: to an acetonitrile solution of 2-amino-4,6-dichloropyrimidine (2.0 g, 12.2 mmol) was added sequentially N,N-diisopropylethylamine (Hunig base, 2.34 mL, 13.4 mmol) and dimethylamine ( 6.7 mL, 13.4 mmol). The reaction mixture was stirred at 50°C for 1.5 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and poured into a mixture of dichloromethane and water. The organic layer was separated, washed with saturated saline, and the organic phase was concentrated to afford 6-chloro-N4,N4-dimethylpyrimidine-2,4-diamine (2.2 g, 94% yield) as an off-white solid.LC-MS (electrospray ionization) m/z = 173,175 [M + H]+. | [References]
[1] Patent: WO2010/59658, 2010, A1. Location in patent: Page/Page column 121
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 3011
[3] Journal of the Chemical Society, 1957, p. 2151
[4] Journal of the Chemical Society, 1952, p. 1532
[5] Organic Magnetic Resonance, 1982, vol. 20, # 4, p. 274 - 275 |
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Energy Chemical
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