100751-63-1

5773-80-8

100751-63-1

General procedure for the synthesis of 6-bromo-2-hydroxymethylnaphthalene from 6-bromo-2-naphthalenecarboxylic acid: To a solution of 6-bromo-2-naphthalenecarboxylic acid (1 g, 3.98 mmol) in tetrahydrofuran (THF, 20 ml) was added a tetrahydrofuran solution of 2M borane dimethyl sulphide (0.53 ml, 5.97 mmol) in batches at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred overnight. After completion of the reaction, the mixture was cooled to 0°C and the reaction was quenched by addition of methanol (MeOH). Subsequently, the solution was concentrated under reduced pressure. The crude product was purified by column chromatography (using ethyl acetate in heptane as eluent) to afford 6-bromo-2-hydroxymethylnaphthalene (0.4 g, 89% yield). lCMS analysis showed m/z 238 [M + H]+ .