| Identification | Back Directory | [Name]
7-CHLORO-3-FORMYLINDOLE | [CAS]
1008-07-7 | [Synonyms]
7-CHLORO-3-FORMYLINDOLE
7-Chloro-3-formyl-1H-indole
7-Chloro-3-indolecarboxaldehyde
1H-Indole-3-carboxaldehyde, 7-chloro- | [Molecular Formula]
C9H6ClNO | [MDL Number]
MFCD06657153 | [MOL File]
1008-07-7.mol | [Molecular Weight]
179.6 |
| Chemical Properties | Back Directory | [Melting point ]
181-182 °C(Solv: ethyl acetate (141-78-6)) | [Boiling point ]
373.4±22.0 °C(Predicted) | [density ]
1.431±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
13.92±0.30(Predicted) | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 7-chloro-1H-indole-3-aldehyde from 7-chloro-1H-indole was as follows: phosphoryl chloride (0.66 mL, 7 mmol) was slowly added dropwise to anhydrous DMF (5 mL) at 0 °C and under argon protection. Subsequently, a solution of 7-chloro-1H-indole (1 g, 6.6 mmol) dissolved in anhydrous DMF (15 mL) was added dropwise to the above mixture at room temperature. The reaction mixture was stirred continuously for 2 hours at room temperature. After completion of the reaction, the mixture was slowly poured into a mixture of ice water and saturated NaHCO3 solution and extracted with ethyl acetate. The organic phases were combined, washed with saturated NaCl solution (10 mL x 3), dried over anhydrous MgSO4, filtered and concentrated to give 990 mg of the target product 7-chloro-1H-indole-3-aldehyde as a yellow-orange solid in 83% yield. | [References]
[1] Patent: US2005/119260, 2005, A1. Location in patent: Page/Page column 36 |
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