| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- | [CAS]
100823-03-8 | [Synonyms]
TC11
CLT-003
5-Amino-2-(2,6-diisopropylphenyl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-
1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11
Cyclin dependent kinase,Apoptotic,Mitotic,Inhibitor,Immunomodulatory,Derivative,inhibit,CDK,TC-11,Bcl-2 Family,TC 11,Antitumor,TC11,Phenylphthalimide,Death,Caspase | [Molecular Formula]
C20H22N2O2 | [MOL File]
100823-03-8.mol | [Molecular Weight]
322.4 |
| Chemical Properties | Back Directory | [Boiling point ]
495.2±55.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
0.76±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
TC11 is a MCL1 degrader and Caspase-9 and CDK1 activator. TC11 functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces degradation of MCL1 leading to apoptotic death [1][2] during prolonged mitotic arrest. | [IC 50]
CDK1; Caspase-9; MCL1 | [References]
[1] Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521(1):252-258. DOI:10.1016/j.bbrc.2019.10.119
[2] Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7(6):e38878. DOI:10.1371/journal.pone.0038878 |
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