| Identification | Back Directory | [Name]
1-[2-[2-(1,1-Dimethylethyl)-5-methylphenoxy]ethyl]-3-methylpiperidine | [CAS]
1008233-79-1 | [Synonyms]
SORT-PGRN interaction inhibitor 2
1-[2-[2-(1,1-Dimethylethyl)-5-methylphenoxy]ethyl]-3-methylpiperidine | [Molecular Formula]
C19H31NO | [MOL File]
1008233-79-1.mol | [Molecular Weight]
289.46 |
| Chemical Properties | Back Directory | [Boiling point ]
394.3±37.0 °C(Predicted) | [density ]
0.944±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
8.74±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
SORT-PGRN interaction inhibitor 2 is a SORT-PGRN inhibitor that can decreases SORT1 protein expression and increases extracellular PGRN secretion in mammalian cell lines. SORT-PGRN interaction inhibitor 2 can be used for neurological disease research[1]. | [References]
[1] Lee WC, et.al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014 Mar 15;23(6):1467-78. DOI:10.1093/hmg/ddt534 |
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