| Identification | Back Directory | [Name]
SB 4 | [CAS]
100874-08-6 | [Synonyms]
SB 4
BMP signaling agonist sb4
Benzoxazole, 2-[[(4-bromophenyl)methyl]thio]- | [Molecular Formula]
C14H10BrNOS | [MDL Number]
MFCD01603921 | [MOL File]
100874-08-6.mol | [Molecular Weight]
320.2 |
| Chemical Properties | Back Directory | [Melting point ]
70-72 °C | [Boiling point ]
444.2±47.0 °C(Predicted) | [density ]
1.57±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
0.92±0.10(Predicted) | [color ]
White to light yellow | [InChI]
1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2 | [InChIKey]
JDVOIBFEFVKUPL-UHFFFAOYSA-N | [SMILES]
BrC1=CC=C(CSC2=NC3=C(C=CC=C3)O2)C=C1 |
| Hazard Information | Back Directory | [Uses]
SB 4 (Eticovo) is a potent and selective agonist of bone morphogenetic protein 4 (BMP4) signaling. | [Biological Activity]
Sb4 is a cell penetrantpotent bone morphogenetic protein (BMP) signaling agonist th at rapidly activate BMP in human renal cells (HEK293). Sb4 activates BMP by stabilization of intracellular p-SMAD-1/5/9. Apparently activation of the BMP pathway by sb4 cannot be reversed by inhibition of Noggin or type I BMP kinase inhibitors | [storage]
Store at -20°C |
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