| Identification | Back Directory | [Name]
(R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester | [CAS]
100927-10-4 | [Synonyms]
(R)-2-N-Boc-propane-1,2-diaMine
(R)-2-(Boc-amino)-1-propanamine
R-2-N-BOC-propane-1,2-diamine-HCl
(R)-2-(Boc-aMino)-propanaMine HCl
(R)-tert-butyl 1-aminopropan-2-ylcarbamate
tert-butyl (R)-1-aMinopropan-2-ylcarbaMate
tert-Butyl (R)-1-aMinopropan-2-ylcarbaMate HCl
tert-butyl N-[(2R)-1-aMinopropan-2-yl]carbaMate
tert-butyl N-[(1R)-2-amino-1-methyl-ethyl]carbamate
(R)-1-Aminopropan-2-ylcarbamic Acid tert-Buty Ester
tert-butyl (R)-1-aMinopropan-2-ylcarbaMate hydrochloride
((R)-2-Amino-1-methyl-ethyl)-carbamic acid tert-butyl ester
N-[(1R)-2-Amino-1-methylethyl]carbamic acid tert-butyl ester
Carbamic acid, N-[(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester
Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI) | [Molecular Formula]
C8H18N2O2 | [MDL Number]
MFCD11112229 | [MOL File]
100927-10-4.mol | [Molecular Weight]
174.24 |
| Chemical Properties | Back Directory | [Boiling point ]
264℃ | [density ]
0.984 | [Fp ]
113℃ | [storage temp. ]
2-8°C(protect from light) | [pka]
12.19±0.46(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Uses]
(R)-1-Aminopropan-2-ylcarbamic Acid tert-Buty Ester is used as an intermediate in the preparation of potent benzothiophene inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK
2). | [Synthesis]
To a stirred solution of tert-butyl (S)-1-azidopropan-2-ylcarbamate (S2-3) (6.0 g, 30 mmol) in ethyl acetate (50.0 mL) was added 10% Pd/C (2.3 g). The reaction mixture was stirred at room temperature under hydrogen atmosphere (1 atm) for 15 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the diatomaceous earth was washed with ethyl acetate. The filtrate was concentrated under reduced pressure to afford tert-butyl N-[(1R)-2-amino-1-methylethyl]carbamate (S2-4) (4.8 g, 92% yield) as a light yellow solid.1H NMR (400 MHz, DMSO-d6) δ 0.95 (d, J = 6.6 Hz, 3H), 1.36 (s, 9H), 2.49 (m, 2H), 3.32 (m, 1H), 6.49 (br s, 1H). | [References]
[1] Patent: US2016/75720, 2016, A1. Location in patent: Paragraph 0247 |
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