| Identification | Back Directory | [Name]
(D-TRP2,7,9)-SUBSTANCE P | [CAS]
100930-11-8 | [Synonyms]
(D-TRP2,7,9)-SUBSTANCE P
ARG-D-TRP-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
H-ARG-D-TRP-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
L-Methioninamide, L-arginyl-D-tryptophyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl- (9CI) | [Molecular Formula]
C80H109N21O13S | [MDL Number]
MFCD00076809 | [MOL File]
100930-11-8.mol | [Molecular Weight]
1604.92 |
| Hazard Information | Back Directory | [Uses]
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with Ki values of 1 μM, 1.3 μM, and ~9 μM for NK-1, NK-2,and NK-3 receptor, respectively[1]. | [IC 50]
NK1: 1 μM (Ki); NK2: 1.3 μM (Ki); NK3: ~9 μM (Ki) | [References]
[1] S H Buck, et al. Agonist and antagonist binding to tachykinin peptide NK-2 receptors. Life Sci. 1988;42(26):2701-8. DOI:10.1016/0024-3205(88)90246-9 |
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