| Identification | Back Directory | [Name]
sandramycin | [CAS]
100940-65-6 | [Synonyms]
sandramycin
L-Valine, N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-seryl-(2S)-2-piperidinecarbonylglycyl-N-methylglycyl-N-methyl-, bimol. (5→1'3),(5'→13)-dilactone
3-hydroxy-N-[23-[(3-hydroxyquinoline-2-carbonyl)amino]-8,11,28,31-tetramethyl-2,6,9,12,15,22,26,29,32,35-decaoxo-7,27-di(propan-2-yl)-5,25-dioxa-1,8,11,14,21,28,31,34-octazatricyclo[34.4.0.0^{16,21}]tetracontan-3-yl]quinoline-2-carboxamide | [Molecular Formula]
C60H76N12O16 | [MDL Number]
MFCD09752757 | [MOL File]
100940-65-6.mol | [Molecular Weight]
1221.32 |
| Hazard Information | Back Directory | [Uses]
Sandramycin is a high molecular weight, symmetric, cyclic depsipeptide belonging to the quinomycin class produced by Kribbella sp.. Sandramycin has potent antitumour and antibacterial activity, and is thought to act by bis-intercalation of DNA. | [Biological Activity]
sandramycin is a cyclic depsipeptide antibiotic that was first isolated from cultured broth of a nocardioides sp [1].sandramycin is an antitumor antibiotic. sandramycin was closely related to the cyclic depsipeptides luzopeptins a, b, c and d. sandramycin exhibited strong inhibition to the gram-positive organisms bacillus subtilis, staphylococcus aureus and streptococcusfaecalis. its antimicrobial activity paralleled that which was observed for echinomycin and luzopeptin a [1]. sandramycin was also a bifunctional dna intercalator that strongly binds dna and forms crosslinks between dna molecules [2].in transplantable mouse leukemia p388, sandramycin was moderately active with values comparable to those for luzopeptin a. injection of 2 mg/kg showed the best increase in life span over the controls (61%) [1]. | [in vivo]
Sandramycin (0.0125-1.6?mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice[1]. | Animal Model: | CDF1 female mice injected with leukemia P388 cells[1] | | Dosage: | 0.0125?mg/kg, 0.025?mg/kg, 0.05?mg/kg, 0.1?mg/kg, 0.2?mg/kg, 0.4?mg/kg, 0.8?mg/kg, 1.6?mg/kg | | Administration: | Intraperitoneal injection; daily; for 5 days | | Result: | Was moderately active in vivo against leukemia P388 in mice.
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| [IC 50]
Traditional Cytotoxic Agents | [References]
[1]. matson ja, bush ja. sandramycin, a novel antitumor antibiotic produced by a nocardioides sp. production, isolation, characterization and biological properties. j antibiot (tokyo). 1989 dec;42(12):1763-7.
[2]. boger dl, saionz kw. dna binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore. bioorg med chem. 1999 feb;7(2):315-21. |
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