| Identification | Back Directory | [Name]
mebikar | [CAS]
10095-06-4 | [Synonyms]
mebikar
Mebicar
Mebican
Temgicoluril
Imidazo[4,5-d]im
Tetramethylglycoluril
Mebicarum/TETRAMETHYLTETRAAZABICYCLOOCTANDION
4,5-(1,3-Dimethylureylene)-1,3-dimethylimidazolidine-2-one
2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]-3,7-oxandione
1,3,4,6-Tetramethyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione
2,4,6,8-Tetramethyl-2,4,6,8-tetraazobicyclo(3.3.0)octane-3,7-dione
1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione
1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-quinone
2,4,6,8-Tetraazabicyclo[3.3.0]octane-3,7-dione, 2,4,6,8-tetramethyl-
Tetrahydro-1,3,4,6-tetramethylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione
2,4,6,8-Tetramethyl-2,4,6,8-tetraazobizykl(3,3,0)oktandion-3,7 [German]
Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetramethyl-
2,4,6,8-Тetramethyl-2,4,6,8,tetraazabycyclo[3.3.0] octane- 3,7-dione, Mebicar
3a,4,6,6a-Tetrahydro-1,3,4,6-tetramethylimidazo[4,5-d]imidazole-2,5(1H,3H)-dione
inhibit,Inhibitor,γ-Aminobutyric acid Receptor,Mebicar,Temgicoluril,Gamma-aminobutyric acid Receptor,GABA Receptor | [Molecular Formula]
C8H14N4O2 | [MDL Number]
MFCD00184215 | [MOL File]
10095-06-4.mol | [Molecular Weight]
198.22 |
| Chemical Properties | Back Directory | [Melting point ]
226 - 229?C | [Boiling point ]
362.2±42.0 °C(Predicted) | [density ]
1.237±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
-0.49±0.20(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
Temgicoluril (Tetramethylglycoluril) is an orally active antianxiety and antidepressant. Temgicoluril acts on GABA receptors to enhance GABA neurotransmission[1][2]. | [Definition]
ChEBI: Mebicar is an imidazolidinone. | [in vivo]
Temgicoluril (10 mg/kg; Oral gavage; 3 weeks) has a preventive effect on neurobehavioral and immunological disruptions caused by intermittent unpredictable stress in mice[2]. | Animal Model: | Intermittent unpredictable stress (IUS) treated seven week-old Balb/cByJ mice[2] | | Dosage: | 10 mg/kg | | Administration: | Oral gavage (i.g.); 3 weeks | | Result: | Recovered rapidly from anxiety-like behavior induced by the multiplexed stress compared with untreated mice.
Did not prevent the decrease of brain-derived neurotropic factor by IUS exposure.
Prevented elevation of serum corticosterone and secretion of proinflammatory cytokines from splenocytes due to IUS exposure.
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| [References]
[1] Val'dman AV, Zaikonnikova IV, Kozlovskaia MM, Zimakova IE. Izuchenie osobennoste? spektra psikhotropnogo de?stviia mebikara [Characteristics of the psychotropic spectrum of action of mebicar]. Biull Eksp Biol Med. 1980 May;89(5):568-70. Russian. PMID:6104993
[2] Kim CY, et al. Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice. Neuroimmunomodulation. 2018;25(1):49-58. DOI:10.1159/000489634 |
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