ChemicalBook--->CAS DataBase List--->101001-34-7

101001-34-7

101001-34-7 Structure

101001-34-7 Structure
IdentificationBack Directory
[Name]

KB 3022
[CAS]

101001-34-7
[Synonyms]

KB 3022
KBT-3022
KB3022 (KBT3022
ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]-pyrrole-1-acetate
ethyl 2-(2-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1H-pyrrol-1-yl)acetate
2-[4,5-Bis(4-methoxyphenyl)thiazol-2-yl]-1H-pyrrole-1-acetic acid ethyl ester
1H-Pyrrole-1-acetic acid, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-, ethyl ester
[Molecular Formula]

C25H24N2O4S
[MOL File]

101001-34-7.mol
[Molecular Weight]

448.53
Chemical PropertiesBack Directory
[Melting point ]

132.5-135.5°
[Boiling point ]

600.3±65.0 °C(Predicted)
[density ]

1.22±0.1 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

DMF:10.0(Max Conc. mg/mL);22.0(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.1(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)
[form ]

A crystalline solid
[pka]

2.68±0.10(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
[Toxicity]

LD50 orally in male mice: >3000 mg/kg (Yoshino)
Spectrum DetailBack Directory
[Spectrum Detail]

KB 3022(101001-34-7)1HNMR
Hazard InformationBack Directory
[Biological Activity]

Pamicogrel (KBT3022) is an inhibitor of cyclooxygenase (COX) with platelet anti-aggregation properties.
[in vitro]

KB 3022 is a cyclooxygenase inhibitor with platelet anti-aggregatory properties which is under development by Kanebo for chronic arterial occlusion. It also has potential in both prophylaxis and treatment of ischemic brain injury.
[target]

TargetValue
COX
()
[storage]

Store at -20°C
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