| Identification | Back Directory | [Name]
KB 3022 | [CAS]
101001-34-7 | [Synonyms]
KB 3022
KBT-3022
KB3022 (KBT3022
ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]-pyrrole-1-acetate
ethyl 2-(2-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1H-pyrrol-1-yl)acetate
2-[4,5-Bis(4-methoxyphenyl)thiazol-2-yl]-1H-pyrrole-1-acetic acid ethyl ester
1H-Pyrrole-1-acetic acid, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-, ethyl ester | [Molecular Formula]
C25H24N2O4S | [MOL File]
101001-34-7.mol | [Molecular Weight]
448.53 |
| Chemical Properties | Back Directory | [Melting point ]
132.5-135.5° | [Boiling point ]
600.3±65.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF:10.0(Max Conc. mg/mL);22.0(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.1(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM) | [form ]
A crystalline solid | [pka]
2.68±0.10(Predicted) | [color ]
Off-white to pink |
| Hazard Information | Back Directory | [Uses]
Pamicogrel (KBT3022) is a cyclooxygenase (COX) inhibitor. | [Biological Activity]
Pamicogrel (KBT3022) is an inhibitor of cyclooxygenase (COX) with platelet anti-aggregation properties. | [in vitro]
KB 3022 is a cyclooxygenase inhibitor with platelet anti-aggregatory properties which is under development by Kanebo for chronic arterial occlusion. It also has potential in both prophylaxis and treatment of ischemic brain injury. | [target]
| Target | Value | COX
() | [IC 50]
Cyclooxygenase | [storage]
Store at -20°C | [References]
[1] Light P. Pamicogrel (Kanebo). IDrugs. 1999 Sep;2(9):938-42. PMID:16121308 |
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| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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Tags:101001-34-7
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