1010100-22-7

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1010100-22-7 Structure

Identification	Back Directory
[Name] ODZXEQVQLJKSQH-UHFFFAOYSA-N
[CAS] 1010100-22-7
[Synonyms] ODZXEQVQLJKSQH-UHFFFAOYSA-N Thalidomide-5-CH2-NH2 (hydrochloride) 5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride 5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride 1H-Isoindole-1,3(2H)-dione, 5-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
[Molecular Formula] C14H14ClN3O4
[MDL Number] MFCD32666042
[MOL File] 1010100-22-7.mol
[Molecular Weight] 323.73

Chemical Properties	Back Directory
[storage temp. ] Keep in dark place,Inert atmosphere,Room temperature
[form ] Solid
[color ] Light yellow to yellow

Hazard Information	Back Directory
[Uses] Thalidomide-5-CH2-NH2 (hydrochloride) is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-CH2-NH2 (hydrochloride) can be connected to the ligand for protein by a linker to form PROTACs[1].
[IC 50] Cereblon
[References] [1] Makbul C, Nassal M, B?ttcher B. Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife. 2020;9:e57277. Published 2020 Aug 14. DOI:10.7554/eLife.57277 [2] Sato T, Ito T, Handa H. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326

Spectrum Detail	Back Directory
[Spectrum Detail] ODZXEQVQLJKSQH-UHFFFAOYSA-N(1010100-22-7)¹HNMR

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