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1010913-79-7

1010913-79-7 Structure

1010913-79-7 Structure
IdentificationBack Directory
[Name]

2-[[2-[2-(2-fluorophenyl)-1,3-thiazol-4-yl]acetyl]amino]acetic acid
[CAS]

1010913-79-7
[Synonyms]

Glycine, N-[2-[2-(2-fluorophenyl)-4-thiazolyl]acetyl]-
2-[[2-[2-(2-fluorophenyl)-1,3-thiazol-4-yl]acetyl]amino]acetic acid
[Molecular Formula]

C13H11FN2O3S
[MOL File]

1010913-79-7.mol
[Molecular Weight]

294.3
Chemical PropertiesBack Directory
[density ]

1.414±0.06 g/cm3(Predicted)
[pka]

3.31±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

SJ6145 is a potent ligand for KLHDC2SBD, with the Kd of 16.9 μM in SPR test, IC50 value of 42 μM in inhibiting KLHDC2SBD binding to a di-Gly degron peptide test[1].
[IC 50]

KLHDC2
[References]

[1] Daniel C Scott, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. DOI:10.1038/s41467-024-52966-3
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