| Identification | Back Directory | [Name]
Cyclopent[f]isoindol-1(2H)-one, 3,5,6,7-tetrahydro-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-phenyl-, (3R)- | [CAS]
1013427-48-9 | [Synonyms]
MR04A3
MR-04A3
MR 04A3
(-)-JM 1232
Cyclopent[f]isoindol-1(2H)-one, 3,5,6,7-tetrahydro-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-phenyl-, (3R)- | [Molecular Formula]
C24H27N3O2 | [MOL File]
1013427-48-9.mol | [Molecular Weight]
389.49 |
| Hazard Information | Back Directory | [Uses]
(-)-JM-1232 (MR04A3) targets GABA A receptors and exerts its analgesic effects by binding to the benzodiazepine binding site of GABA A receptors. (-)-JM-1232 demonstrates potent analgesic effects in mice against acute thermal stimuli, mechanically induced pain, and visceral pain, with CI50 values of 2.96, 3.06, and 2.27 mg/kg, respectively. (-)-JM-1232 can be used in research related to pain and analgesia[1][2]. | [References]
[1] Nishiyama T, et al. Antinociceptive property of intrathecal and intraperitoneal administration of a novel water-soluble isoindolin-1-one derivative, JM 1232 (-) in rats. Eur J Pharmacol. 2008 Oct 31;596(1-3):56-61. DOI:10.1016/j.ejphar.2008.07.054
[2] Chiba S, et al. The antinociceptive effects and pharmacological properties of JM-1232(-): a novel isoindoline derivative. Anesth Analg. 2009 Mar;108(3):1008-14. DOI:10.1213/ane.0b013e318193678f |
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