| Identification | Back Directory | [Name]
N-ACETYLTRYPTAMINE | [CAS]
1016-47-3 | [Synonyms]
Acetotryptamide
N-ACETYLTRYPTAMINE
N-(2-(1H-Indol-3-yl)
TRYPTAMINE, N-ACETYL-
N-Acetyltryptamine >
N-Acetyltryptamine
3-(2-Acetamidoethyl)indole
3-(2-N-ACETYLAMINOETHYL)INDOLE
N-Acetyl-1H-indole-3-ethaneamine
Acetamide,N-(2-indol-3-ylethyl)-
3-[2-(Acetylamino)ethyl]-1H-indole
N-[2-(1H-indol-3-yl)ethyl]ethanamide
N-[2-(1H-Indol-3-yl)-ethyl]-acetamide
Acetamide,N-[2-(1H-indol-3-yl)ethyl]- | [Molecular Formula]
C12H14N2O | [MDL Number]
MFCD00209910 | [MOL File]
1016-47-3.mol | [Molecular Weight]
202.25 |
| Chemical Properties | Back Directory | [Melting point ]
74.0 to 78.0 °C | [Boiling point ]
200°C/0.2mmHg(lit.) | [density ]
1.164±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
alcohol: soluble
| [form ]
powder
| [pka]
16.48±0.46(Predicted) | [color ]
White to Light yellow to Light orange | [λmax]
290nm(MeOH)(lit.) | [CAS DataBase Reference]
1016-47-3 |
| Hazard Information | Back Directory | [Description]
N-acetyl Tryptamine is a structural analog of melatonin (5-methoxy-N-acetyltryptamine; ) that binds the melatonin MT2 receptor (Ki = 41 nM). It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina. N-acetyl Tryptamine is also a reaction product of assays for serotonin N-acetyltransferase, the penultimate enzyme in the melatonin biosynthetic pathway. | [Description]
The Argentinian medicinal plant Prosopsis nigra contains this alkaloid of the simple
indole type which has recently been isolated and characterized. It may be a direct
precursor in the biosynthesis of the {:l-carboline bases. | [Uses]
N-acetyl Tryptamine is a structural analog of melatonin (5-methoxy-N-acetyltryptamine; ) that binds the melatonin MT2 receptor (Ki = 41 nM). It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina. N-acetyl Tryptamine is also a reaction product of assays for serotonin N-acetyltransferase, the penultimate enzyme in the melatonin biosynthetic pathway. | [Definition]
ChEBI: A tryptamine compound having an acetyl substituent attached to the side-chain amino function. | [Enzyme inhibitor]
This partial receptor agonist (FW = 202.26 g/mol; CAS 1016-47-3; Soluble
to 100 mM in DMSO) is a melatonin (or 5-methoxy-N-acetyltryptamine)
mimic and is more potent than melatonin in inhibiting dopamine release
fom presynaptic melatonin receptor site of rabbit retina labeled in vitro
with [3H]dopamine. | [storage]
Store at RT | [References]
Moro, Graziano, Coussio, Phytochern., 14,827 (1975) |
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