| Identification | Back Directory | [Name]
Carbamic acid, N-(3'-chloro-4'-hydroxy[1,1'-biphenyl]-2-yl)-, 1-[9-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]nonyl]-4-piperidinyl ester | [CAS]
1017857-38-3 | [Synonyms]
β2AR/M-receptor agonist-2
Carbamic acid, N-(3'-chloro-4'-hydroxy[1,1'-biphenyl]-2-yl)-, 1-[9-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]nonyl]-4-piperidinyl ester | [Molecular Formula]
C36H49ClN4O7S | [MOL File]
1017857-38-3.mol | [Molecular Weight]
717.31 |
| Hazard Information | Back Directory | [Uses]
β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD)[1]. | [in vivo]
β2AR/M-receptor agonist-2 dose-dependently inhibits methacholine-induced bronchoconstriction in dogs with an ID50 value of 50 mg[1]. | [References]
[1] Laura Hilton, et al. Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. MedChemComm. 2011. |
|
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|