| Identification | Back Directory | [Name]
PYRROLNITRIN | [CAS]
1018-71-9 | [Synonyms]
52230
A-10338
pyroace
nsc-107654
pyrollnitrin
Antibiotic A-10338
3-chloro-4-(3-chloro-2-nitrophenyl)-pyrrol
3-chloro-4-(2’-nitro-3’-chlorophenyl)pyrrole
PYRROLE,3-CHLORO-4-(3-CHLORO-2-NITROPHENYL)-
3-chloro-4-(3-chloro-2-nitrophenyl)-1H-pyrrole
3-chloro-4-(3-chloro-2-nitro-phenyl)-1H-pyrrole
1H-Pyrrole, 3-chloro-4-(3-chloro-2-nitrophenyl)- | [EINECS(EC#)]
213-812-7 | [Molecular Formula]
C10H6Cl2N2O2 | [MDL Number]
MFCD00865605 | [MOL File]
1018-71-9.mol | [Molecular Weight]
257.07 |
| Chemical Properties | Back Directory | [Melting point ]
124.5° | [Boiling point ]
410.5±45.0 °C(Predicted) | [density ]
1.5834 (rough estimate) | [refractive index ]
1.6100 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 10 mM | [form ]
A solid | [pka]
14.28±0.50(Predicted) | [color ]
Light green to green | [InChI]
1S/C10H6Cl2N2O2/c11-8-3-1-2-6(10(8)14(15)16)7-4-13-5-9(7)12/h1-5,13H | [InChIKey]
QJBZDBLBQWFTPZ-UHFFFAOYSA-N | [SMILES]
[O-][N+](=O)c1c(Cl)cccc1-c2c[nH]cc2Cl |
| Safety Data | Back Directory | [WGK Germany ]
WGK 2 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | [Toxicity]
LD50 in rats, rabbits (mg/kg): 68, 105 i.p. (Nishida) |
| Hazard Information | Back Directory | [Description]
Pyrrolnitrin, isolated from Pseudomonas
species, is highly active against fungi,
particularly trichophyte species. | [Uses]
Antifungal. | [Definition]
ChEBI: A member of the class of pyrroles carrying chloro and 3-chloro-2-nitrophenyl substituents at positions 3 and 4 respectively. | [Origin]
Pyrrolnitrin was found in the cells of Pseudomonas pyrrocinia grownin a medium containing a high concentration of inorganic phosphate.It was discovered by Arima of the University of Tokyo in collaboration with Fujisawa Pharmaceutical Industries Co. in 1965. | [Biological Activity]
Pyrrolnitrin shows strong activity against a variety of fungi and weak activity against grampositive bacteria.
| [Biochem/physiol Actions]
Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis. | [storage]
Store at -20°C |
|
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Finetech Industry Limited
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+86-27-8746-5837 +86-18627785180 |
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NORANA GROUP
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027-59209883 17386169806 |
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www.nornachem.com |
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Wuhan Topule
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http://www.topule.com/ |
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