| Identification | Back Directory | [Name]
(2-Chloro-7H-purin-6-yl)-furan-2-ylmethyl-amine | [CAS]
101862-47-9 | [Synonyms]
2-Chloro-N6-furfuryladenine
2-Chloro-N-(furan-2-ylmethyl)-9H-purin-6-amine
(2-Chloro-7H-purin-6-yl)-furan-2-ylmethyl-amine | [Molecular Formula]
C10H8ClN5O | [MDL Number]
MFCD09792860 | [MOL File]
101862-47-9.mol | [Molecular Weight]
249.66 |
| Chemical Properties | Back Directory | [Melting point ]
241-242 °C | [Boiling point ]
388.3±52.0 °C(Predicted) | [density ]
1.69±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO:24.97(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
Solid | [pka]
6.99±0.20(Predicted) | [color ]
White to Off-White | [InChI]
1S/C10H8ClN5O/c11-10-15-8(7-9(16-10)14-5-13-7)12-4-6-2-1-3-17-6/h1-3,5H,4H2,(H2,12,13,14,15,16) | [InChIKey]
QGUOPVCOXHVPJX-UHFFFAOYSA-N | [SMILES]
Clc1nc2[nH]cnc2c(n1)NCc3[o]ccc3 |
| Hazard Information | Back Directory | [Uses]
2-Chloro-N-[(furan-2-yl)methyl]-7H-purin-6-amine is a chlorinated Kinetin (K570005) which is a cell division factor found in various plant parts and in yeast. 2-Chloro-N-[(furan-2-yl)methyl]-7H-purin-6-amine is used in the synthesis of zinc and copper complexes. | [Biological Activity]
Orally activeCDC2-like kinase 1 (CLK1) allosteric activator th at enhances promotes CLK1/SRSF5 pathway-mediated pre-mRNA splicing events.
RECTAS is an orally activeCDC2-like kinase 1 (CLK1) allosteric activator th at enhances SRSF6 c-terminal RS domain phosphorylation by CLK1thereby promoting CLK1/SRSF5 pathway-mediated pre-mRNA splicing events. RECTAS restores IKBKAP-familial dysautonomia (FD) exon 20 inclusion in cultured cells (2-10 μM; FD patient iPSC-SNs & murine neuro 2A cells) and in IKBKAP-FD transgenic mice in vivo (two p.o. doses of 300 or 400 mg/kg 4h apart). RECTAS suppresses MC38 tumor growth (by 37/47% at 10/25 μM at the end of 33-day treatment via daily intratumoral injection) by reducing aberrant splicing events and enhancing the splice-neoantigens production. | [storage]
Store at -20°C |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
TargetMol
|
| Tel: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
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