| Identification | Back Directory | [Name]
Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl- | [CAS]
1018830-99-3 | [Synonyms]
VCP171
VPC171
Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-
(2-Amino-4-(3-(trifluoromethyl)phenyl)thiophen-3-yl)(phenyl)methanone | [Molecular Formula]
C18H12F3NOS | [MDL Number]
MFCD34601853 | [MOL File]
1018830-99-3.mol | [Molecular Weight]
347.35 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml,Ethanol: 10 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Biological Activity]
VCP171 is a positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 μM in a kinetic assay measuring agonist dissociation).1. It reduces AMPA receptor-mediated evoked excitatory postsynaptic currents (eEPSCs) in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 μM, respectively) to a greater extent than in sham control animals (EC50s = 2.512 and 0.631 μM, respectively).2 | [storage]
Store at -20°C | [References]
1.Aurelio, L., Figler, H., Flynn, B.L., et al.5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancersBioorg. Med. Chem.16(3)1319-1327(2008)
2.Imlach, W.L., Bhola, R.F., May, L.T., et al.A positive allosteric modulator of the adenosine A1 receptor selectively inhibits primary afferent synaptic transmission in a neuropathic pain modelMol. Pharm.88(3)460-468(2015)
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